Curriculum Vitae —
— Michèl Schummer, PhD

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Objective

I have over 20 years of experience in cancer biomarkers, teaching and database development/administration. I am seeking a challenge where I can combine my experience in any of these fields with my language skills, potentially working abroad and/or with disadvantaged communities.


Cancer Biology

My background lies in molecular genetics applied to cancer biomarkers, as well in the generation of tools that benefit the discoveries. During my career, I progressed from bench scientist to manager while taking on additional responsibilities including a clinical marker laboratory and a specimen repository. I wrote and co-wrote over 40 successfully funded grant proposals and I authored over 30 research papers. My professional scientific career spans 17 years:


Consultant for Biotechnology Companies and Academic Institutions: Cancer biomarkers, management of databases, specimen repositories – since 2016  

Staff Scientist, Fred Hutchinson Cancer Research Center, Seattle, Washington: Management of blood assay development; management of a CLIA-certified marker testing laboratory; management of a specimen repository; creation and management of databases; supervision of research projects and personnel; writing of grant proposals, reports and publications; liaison between bench scientists and clinical personnel at Swedish Medical Center – 2005 to 2015  

Scientist 2, MacroGenics Inc. Rockville, Maryland: Development of cancer biomarkers using mass spectrometry and DNA tools; management of IT infrastructure; creation and administration of research-specific databases; writing of small business grant proposals – 2001 to 2005  

Senior Scientist, Institute for Systems Biology, Seattle, Washington: Supervision of research projects and personnel for ovarian cancer biomarker discovery; writing of grant proposals, reports and publications – 2000 to 2001  

Research Associate, University of Washington, Seattle, Washington: Discovery of a blood-based marker for the early detection of ovarian cancer, which is now used clinically – 1998 to 2000  


Teaching

I started tutoring at the age of 21, giving guitar lessons and being a big brother to children from single mothers. Since then, I have continuously tutored or taught in one way or another, preferentially in a one-on-one setting.

My teaching focuses on the student, their specific needs, their experiences and their immediate goals. If I am tutoring a student whose French is acceptable but his confidence is low, I might start cooking with him while making him talk with me. If I teach science, it includes the principles of gaining knowledge and how they can be used universally. This applies to high school students as well as my staff, who will additionally receive training by other parties. I strife to instill curiosity in my students and boost independent thinking. I have been teaching for 22 years:


Supervision of university student interns, Fred Hutchinson Cancer Research Center, Seattle, Washington – 2005 to 2014  

Supervision of a post-doctoral fellow, Fred Hutchinson Cancer Research Center, Seattle, Washington – 2005 to 2006  

Supervision of student interns, Institute for Systems Biology, Seattle, Washington, high school students and freshmen university students – 2000 to 2001  

Instructor at the Institute for Science Training and Research, Seattle, Washington, teaching adults about newly emerging biotechnology tools and their applications – 1998 to 2003 

Teaching introductory courses in an advanced biology class at Garfield High School, Seattle, Washington – 1998 to 2001  

Participant in the Outreach Program at University of Washington and later the Institute for Systems Biology, Seattle, Washington, working in family science through interaction with primary school children at their schools, at Seattle Woodland Park Zoo or at Seattle Aquarium – 1997 to 2001  

Supervision of student interns, University of Washington, Seattle, Washington – 1997 to 2000  

Summer Student Program for students from from disadvantaged families, University of Washington, Seattle, Washington – 1995 to 1999  


Database Programming

I design databases from the user's perspective using results-oriented programming. My databases start small and tailored to a specific project. Those with continued usefulness are redesigned for a larger user base and morph into more conventional databases. During the design process I choose to be close to the user and watch them interact with the interface. This in turn allows me to change interface elements on the fly to accommodate the workflow of an individual or a group. I have been programming databases for 26 years:


FileMaker Go: Expanding existing and creating new solutions accessible on iOS (and the web interface on other devices), such as databases for specimen inventory with barcode scanning; expenses for data entry at the time of payment; scheduling and invoicing for small medical practices – since 2010

FileMaker Server: Porting existing databases to server-based solutions for a greater number people throughout an organization and by collaborators outside an organization. In particular, databases were used for gene and protein expression management; for biorepository management of patient characteristics, their tissues and their locations in the freezers; for invoicing of specimens; for laboratory results tracking; and for synchronization with FoxPro and SQL Server databases – since 1999

FileMaker Pro: Starting with simple personal databases, such as diaries, contacts and shopping lists, I progressed to professional ad-hoc solutions for laboratory personnel, including databases for oligonucleotides, tissue sources and DNA microarray data – since 1997

MS Access: Adaptation of existing contacts databases for ease-of-use in public relation offices – 1993 to 1994

dBASE IV: Learning database programming; creation of various personal databases – 1991 to 1993

Educational Background

University of Washington, Seattle WA, Post Doc in Molecular Biotechnology – 1995 to 1998

Trainee, Public Relations, German Cancer Research Center, Heidelberg, Germany – 1995

Trainee, Public Relations Office, German Cancer Society, Frankfurt/Main, Germany – 1994

University of Heidelberg: PhD in Molecular Biology – 1994

Graduate Student, Centre for Molecular Biology, University of Heidelberg, Germany – 1991 to 1994

University of Heidelberg: Diploma in Biology – 1991

Research Student, Centre for Molecular Biology, University of Heidelberg, Germany – 1989 to 1991

Research Student, Weizmann Institute of Science, Rehovot, Israel – 1989

Research Student, Department of Zoology, University of Heidelberg, Germany – 1986 to 1988

Awards

Scholar Award, Marsha Rivkin Center for Ovarian Cancer Research – 2000 to 2001

Post-doctoral fellowship award, Deutsche Forschungsgemeinschaft – 1995 to 1996

Research Papers in Refereed Journals

Schummer M, Thorpe J, Giraldez M, Bergan L, Tewari M, Urban N (2015) Evaluating Serum Markers for Hormone Receptor-Negative Breast Cancer. PLoS One 10(11):e0142911.

Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP (2013) Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A 110:6109-14.

Schummer M, Drescher C, Forrest R, Gough S, Thorpe J, Hellström I, Hellström KE, Urban N (2011) Evaluation of ovarian cancer remission markers HE4, MMP7 and Mesothelin by comparison to the established marker CA125. Gynecol Oncol. 125:65-69.

Ventura AP, Radhakrishnan S, Green A, Rajaram SK, Allen AN, O’Briant K, Schummer M, Karlan B, Urban N, Tewari M, Drescher C, Knudsen BS (2010) Activation of the MEK - S6 pathway in high-grade ovarian cancers. Applied Immunohistochemistry and Molecular Morphology 18: 499-508.

Schummer M, Green A, Beatty JD, Karlan BY, Karlan S, Gross J, Thornton S, McIntosh M, Urban N (2010) Comparison of Breast Cancer to Healthy Control Tissue Discovers Novel Markers with Potential for Prognosis and Early Detection. PLoS ONE 5: e9122.

Faça VM, Ventura AP, Fitzgibbon MP, Pereira-Faça SR, Pitteri SJ, Green AE, Ireton RC, Zhang Q, Wang H, O’Briant KC, Drescher CW, Schummer M, McIntosh MW, Knudsen BS, Hanash SM (2008) Proteomic Analysis Of Ovarian Cancer Cells Reveals Dynamic Processes Of Protein Secretion And Shedding Of Extra-Cellular Domains. PLoS ONE 3:e2425.

Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellström KE (2003) The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res, 63: 3695-700.

Pepe MS, Longton G, Anderson G, Schummer M (2003) Selecting Differentially Expressed Genes from Microarray Experiments. Biometrics, 59: 133-42.

Stone B, Schummer M, Paley PJ, Thompson L, Stewart J, Ford M, Crawford M, Urban N, O'Briant K, Nelson BH (2003) Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q. Int J Cancer, 104: 73-84.

Fang X, Schummer M, Mao M, Yu S, Tabassam FH, Swaby R, Hasegawa Y, Tanyi JL, LaPushin R, Eder A, Jaffe R, Erickson J and Mills GB (2002) Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim Biophys Acta, 1582: 257-64.

Park I, He Y, Lin F, Lærum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L (2002) Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells. Blood, 99: 488-98

Stone B, Schummer M, Paley PJ, Crawford M, Ford M, Urban N and Nelson BH (2001) MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. Gene, 267: 173-82.

Furey TS, Cristianini N, Duffy N, Bednarski DW, Schummer M, Haussler D (2000) Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioinformatics, 16: 906-14.

Ben-Dor A, Bruhn L, Friedman N, Nachman I, Schummer M and Yakhini Z (2000) Tissue Classification with Gene Expression Profiles. The Forth Annual International Conference on Computational Molecular Biology – Recombinant DNA technical bulletin 2000, pp 54-64 .

Keller A, Schummer M, Hood L, Ruzzo WL (2000) Bayesian Classification of DNA Array Expression Data. Technical Report, UW-CSE-2000-08-01, August, 2000.

Ben-Dor A, Bruhn L, Friedman N, Nachman I, Schummer M and Yakhini, Z (2000) Tissue classification with gene expression profiles. Journal of Computational Biology, 7: 559-84.

Schummer M, Kiviat N, Bednarski D, Crumb GK, Ben-Dor A, Drescher C and Hood L (2000) Hybridisation of an array of 100,000 cDNAs with 32 tissues finds potential ovarian cancer marker genes, Int. J. Biol. Markers, 15 suppl. 1: 35.

Gauchat D, Mazet F, Berney C, Schummer M, Kreger S, Pawolowski J and Galliot B (2000) Evolution of Antp class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning, Proc. Natl. Acad. Sci. USA, 97: 4493-8.

Nelson PS, Ng WL, Schummer M, Bumgarner R, Ferguson C, and Hood L (1999) Negative selection: a method for obtaining low-abundance cDNAs using high-density cDNA clone arrays. Genet. Anal. 15: 209-15.

Zong Q, Schummer M, Hood L, Morris DR (1999) Messenger RNA Translation State: The Second Dimension of High-Throughput Expression Screening, Proc. Natl. Acad. Sci. USA, 96: 10632-6.

Schummer M, Ng WL, Bumgarner RE, Nelson PS, Schummer B, Hassell L, Rae Baldwin L, Karlan BY, and Hood L (1999) Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene 238: 375-85.

Wang K, Gan L, Jeffrey E, Gayle M, Gown AM, Skelly M, Nelson PS, Ng W, Schummer M, Hood L and Mulligan J (1999) Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray, Gene, 229: 101-8.

Schummer B, Hauptfleisch S, Siegsmund M, Schummer M and Lemmer B (1998) Highly Accurate Quantification of mRNA Expression by Means of Titan™ One Tube RT-PCR and Capillary Electrophoresis, Biochemica, 2: 31-3.

Ng W-L, Goo YA, Schummer M, Schuder L, Baldwin RL, Karlan BY and Hood L (1998) Identification of ovarian tumor-related genes using a combination of high-throughput technologies, Proc. Am. Assoc. Cancer Res. 39: 453.

Nelson PS, Ng WL, Schummer M, True L, Liu AL, Bumgarner R, Ferguson C, Dimak A, and Hood L. (1998) An Expressed-Sequence-Tag Database of the Human Prostate: Sequence Analysis of 1,168 cDNA Clones, Genomics, 47: 12-25.

Schummer B, Petroianu G, Schummer M, Maleck W, Rüfer R (1997) The efficiency of placental protection against foetal cell passage into the maternal circulation: A PCR based study for the male ZFY gene in maternal blood of minipig, Scandinavian J of Lab Animal Sci. 25 Suppl. 1: 225-9.

Schummer M, Ng WL, Nelson PS, Bumgarner RB and Hood L (1997) A simple high-performance DNA arraying device for comparative expression analysis of a large number of genes, BioTechniques, 23: 1087-92.

Galliot B, Kreger S, Rungger D, Schummer M and Gauchat D (1997) Regulatory genes involved in Hydra pattern formation and nerve differentiation, Proceedings of the 6th International Conference on Coelenterate Biology, 1995: 167-75.

Ng W-L, Schummer M, Cirisano, F, Baldwin RL, Karlan BY and Hood L (1996) High-Throughput Plasmid Minipreparations Facilitated By Micro-Mixing, Nucl. Acids Res, 24: 5045-7.

Galliot B and Schummer M (1993) "Guessmer" screening strategy applied to species with A/T rich coding sequences, Trends Genet, 9: 3-4.

Schummer M, Scheurlen I, Schaller C and Galliot B (1992) HOX/HOM homeogenes are present in Hydra (Chlorohydra viridissima) and are differentially expressed during regeneration, EMBO J, 11: 1815-23

Other Publications

Schummer M, Beatty JD, Urban N (2010) Breast Cancer Genomics: Normal Tissue and Cancer Markers. Annals NY Acad Sci 1210: 78-85.

Wall Street Journal article (2004) about progress in early detection of ovarian cancer

Books

Schummer M, Ng WL, Nelson PS, Bumgarner RB and Hood L (1999) Inexpensive Handheld Device for the Construction of High-Density Nucleic Acid Arrays, in: Expression Genetics: Accelerated and High-Throughput Methods, ed. M McClelland and A. Pardee, BioTechiques Books, Natick, MA. 1999; 3-11.

Zong Q, Schummer M and Morris D (1998) Analysis of translationally controlled genes by DNA array, Cold Spring Harbor Laboratory, New York. 

Speaker

“Ovarian cancer markers – CA125, HE4 and beyond”, University of Minnesota, Minneapolis MN, October 2012

“Breast Cancer Genomics: Normal Tissue and Cancer Markers”, Conference Towards Personalized Medicine", NY Academy of Sciences and Talència, Catalonian Research Organization, Barcelona, Spain, May 2010

“Breast Cancer Genomics: Normal Tissue and Cancer Markers”, German Cancer Research Center, Heidelberg, Germany, May 2010

“Discovery of potential breast cancer markers by measuring transcript in tissue”, qPCR Symposium USA, Clarion Hotel San Francisco Airport, Millbrae CA, November 2009

“Systemic approach to the discovery of cancer markers for the ovary and prostate”, University Hospital Eppendorf, University of Hamburg, Germany, June 2002

“Multiple approaches lead to the discovery of new cancer markers”, Huntsman Cancer Institute, University of Utah, Salt Lake City UT, May 2001

"Discovery of new ovarian cancer markers by microarray hybridisation", Institute of Pathology, Cambridge, UK, and Pasteur, Institute Paris, France, June 2000

"Discovery of new ovarian cancer markers by microarray hybridization", Southwest Oncology Group, Seattle WA, June 2000

"Using High Density Array Hybridization to Discover Potential Marker Genes for Ovarian Cancer", Corixa Corp., Seattle, February 1999 and ZymoGenetics Inc. Seattle WA, April 1999

"A Net for Fishing in a Sea of Genes - Using Statistical Methods to Screen DNA Chip Hybridization Output", Marsha Rivkin Center, Seattle WA, August 1998

"Using high-density cDNA arrays for detection of differentially expressed genes in ovarian cancer tissues", Fred Hutchinson Cancer Research Center, Seattle WA, June 1996

Institutional Service

Associate Editor, BMC Cancer – 2001-present

Reviewer, Breast Cancer Panel, Department of Defense, Washington, DC – 2009-2011

Member, Specimen Review Committee for the Pacific Ovarian Cancer Research Consortium, Fred Hutchinson Cancer Research Center, Seattle, WA – 2005-2015

Founder and Editor, Student Newspaper, University of Heidelberg, Germany  – 1987-1989

Inventions and Patents

A hand-held arraying and replication device (ARD) for manual generation of high-density cDNA and colony arrays, licenced to V&P Scientific, San Diego, CA, USA.

HE4 sandwich ELISA as a diagnostic marker for ovarian cancer. Filed for patent protection on 30 August 2001. 

Languages

Fluent in English, French and German. Reading and simple conversations in Spanish, Italian and Arabic. Reading and basic understanding of Dutch, Portuguese, Modern Greek and Modern Hebrew. Familiarity with Hungarian, Serbian, Chinese and Danish.

Programming FileMaker databases. Familiar with R, Perl and Unix shell scripts. Unix, Macintosh and Windows System administration. Web authoring using responsive design tools.

Other

Performances in small local venues (voice and guitar)

Financial officer of a condo association

Active in neighborhood politics

20 years of involvement in a developmental aid association in Uganda

20 years of involvement in a charitable organization benefiting people with AIDS